Palladium‐Catalysed Amide‐Directed Ligand Free C8‐Olefination of 1‐Naphthamides for the synthesis of 2,3‐dihydro‐1 H ‐benzo[ de ]isoquinolin‐1‐ones

This work describes the palladium(II)‐catalyzed regioselective C8‐H olefination of 1‐naphthamides. Interestingly, naphthamide fused lactam 2,3‐dihydro‐1H‐benzo[ de ]isoquinolin‐1‐one derivatives were also synthesized in the case of a particular class of napthamides. This protocol was found well comp...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-02, Vol.366 (4), p.838-843
Main Authors: Maji, Suman, Pradhan, Sukumar, Pidiyara, Karishma, Maiti, Siddhartha, Al‐Thabaiti, Shaeel A., Maiti, Debabrata
Format: Article
Language:English
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Summary:This work describes the palladium(II)‐catalyzed regioselective C8‐H olefination of 1‐naphthamides. Interestingly, naphthamide fused lactam 2,3‐dihydro‐1H‐benzo[ de ]isoquinolin‐1‐one derivatives were also synthesized in the case of a particular class of napthamides. This protocol was found well compatible with a diverse range of acrylates and styrenes leading to product formation in good yields along with a wide functional group tolerance. The developed strategy was further applied to the synthesis of different drug derivatives.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202300483