DMSO/SOCl 2 ‐Mediated Synthesis of Thiomethylnaphthalenes from Propargyl Alcohols

Herein, we reported the straightforward synthesis of thiomethylnaphthalenes via the reaction of propargyl alcohols with dimethyl sulfoxide/thionyl chloride (DMSO/SOCl 2 ), which also provided easy access to deuterated thiomethyl and other thioalkyl scaffolds when deuterated dimethyl sulfoxide and di...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2024-11
Main Authors: Wang, Zhihua, Liang, Wang‐Fu, He, Xinglei, Li, Jingheng, Ye, Ke‐Yin
Format: Article
Language:English
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Summary:Herein, we reported the straightforward synthesis of thiomethylnaphthalenes via the reaction of propargyl alcohols with dimethyl sulfoxide/thionyl chloride (DMSO/SOCl 2 ), which also provided easy access to deuterated thiomethyl and other thioalkyl scaffolds when deuterated dimethyl sulfoxide and dialkyl sulfoxides were used, respectively. In addition, the thiomethyl group can be readily derivatized to the corresponding sulfoxide, sulfone, and sulfoximine of interesting photophysical properties.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202401025