A H 2 O 2 -Supplied Supramolecular Material for Post-irradiated Infected Wound Treatment

• Published in: Advanced science 2023-03, Vol.10 (9), p.e2206851
• Main Authors: Du, Peidong, Shen, Yanzhe, Zhang, Baoli, Li, Shan, Gao, Minzheng, Wang, Ting, Ding, Xiaokang, Yu, Bingran, Wang, Zhen-Gang, Xu, Fu-Jian
• Format: Article
• Language: English
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Escherichia coli; Hydrogels - therapeutic use; Methicillin-Resistant Staphylococcus aureus; Photochemotherapy; Rats; Riboflavin - pharmacology; Wound Infection - drug therapy
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202206851

Photodynamic therapy (PDT) is a light triggered therapy by producing reactive oxygen species (ROS), but traditional PDT may suffer from the real-time illumination that reduces the compliance of treatment and cause phototoxicity. A supramolecular photoactive G-quartet based material is reported, which is self-assembled from guanosine (G) and 4-formylphenylboronic acid/1,8-diaminooctane, with incorporation of riboflavin as a photocatalyst to the G4 nanowire, for post-irradiation photodynamic antibacterial therapy. The G4-materials, which exhibit hydrogel-like properties, provide a scaffold for loading riboflavin, and the reductant guanosine for the riboflavin for phototriggered production of the therapeutic H O . The photocatalytic activity shows great tolerance against room temperature storage and heating/cooling treatments. The riboflavin-loaded G4 hydrogels, after photo-irradiation, are capable of killing gram-positive bacteria (e.g., Staphylococcus aureus), gram-negative bacteria (e.g., Escherichia coli), and multidrug resistant bacteria (methicillin-resistant Staphylococcus aureus) with sterilization ratio over 99.999%. The post-irradiated hydrogels also exhibit great antibacterial activity in the infected wound of the rats, revealing the potential of this novel concept in the light therapy.