Very low dose warfarin as prophylaxis against ultrasound detected deep vein thrombosis following primary hip replacement

One mg daily warfarin was compared to variable dose warfarin (PT 1.3–1.5 times the normal PT), as prophylaxis against deep vein thrombosis (DVT) following unilateral hip replacement for degenerative joint disease (DJD). Ninety‐eight patients entered onto study after having had negative color Doppler...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hematology 2002-10, Vol.71 (2), p.69-74
Main Authors: Bern, Murray M., Bierbaum, Benjamin, Wetzner, Steven, Brennan, William, McAlister, Sheila
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
anticoagulation
Arthroplasty, Replacement, Hip - adverse effects
Arthroplasty, Replacement, Hip - methods
Biological and medical sciences
Blood Loss, Surgical
Blood. Blood coagulation. Reticuloendothelial system
deep vein thrombosis
Dose-Response Relationship, Drug
Female
hip replacement
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prothrombin Time
thrombosis
Treatment Outcome
Ultrasonography, Doppler, Duplex
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - drug therapy
Venous Thrombosis - prevention & control
warfarin
Warfarin - administration & dosage
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:One mg daily warfarin was compared to variable dose warfarin (PT 1.3–1.5 times the normal PT), as prophylaxis against deep vein thrombosis (DVT) following unilateral hip replacement for degenerative joint disease (DJD). Ninety‐eight patients entered onto study after having had negative color Doppler ultrasounds of the legs. Patients receiving 1 mg began therapy 7 days preoperatively and continued daily until discharge. Patients receiving the variable dose took 5 mg the night preoperatively, and thereafter daily based upon the daily PT. Seventy‐eight patients completed the study protocol. No patient completing the protocol had DVT or pulmonary embolus (PE). Based upon intent to treat for all registered patients, one from each group had DVT after withdrawal from study. For patients receiving 1 mg warfarin daily, PTs extended none or slightly. Therefore, 1 mg warfarin can be used to prevent postoperative DVT following elective hip surgery. Am. J. Hematol. 71:69–74, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.10171