Unexplained bone marrow granulomas: Is amiodarone the culprit? A report of 2 cases

Granulomas in the bone marrow are usually caused by infectious or hematological diseases, and drugs are only rarely implicated as causative agents. Recent reports have drawn attention to the role of amiodarone in the etiology of bone marrow granulomas. We report two cases of amiodarone‐induced bone...

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Bibliographic Details
Published in:American journal of hematology 2004-02, Vol.75 (2), p.110-112
Main Authors: Mukhopadhyay, Surabhi, Mukhopadhyay, Sanjay, Abraham, Naif Z., Jones, Lee A., Howard, Leslie, Gajra, Ajeet
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
amiodarone
Amiodarone - adverse effects
Anti-Arrhythmia Agents - adverse effects
Atrial Fibrillation - drug therapy
Biological and medical sciences
Biopsy, Needle
bone marrow
Bone Marrow - drug effects
Bone Marrow - pathology
Granuloma - chemically induced
Granuloma - pathology
granulomas
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Middle Aged
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Summary:Granulomas in the bone marrow are usually caused by infectious or hematological diseases, and drugs are only rarely implicated as causative agents. Recent reports have drawn attention to the role of amiodarone in the etiology of bone marrow granulomas. We report two cases of amiodarone‐induced bone marrow granulomas in patients being investigated for refractory anemia and pancytopenia, respectively. Since both patients had life‐threatening arrhythmias, discontinuation of the drug followed by rechallenge was not possible. Both patients did well in spite of continued amiodarone therapy, indicating that the underlying hematological illnesses were unrelated to the granulomas. Amiodarone should be considered as a possible cause of bone marrow granulomas after the exclusion of other causes. Continued use of amiodarone after granuloma formation must be dictated by the underlying cardiac condition. Am. J. Hematol. 75:110–112, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.10465