Thalidomide in POEMS syndrome: Case report

We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after...

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Bibliographic Details
Published in:American journal of hematology 2004-05, Vol.76 (1), p.66-68
Main Authors: Sinisalo, Marjatta, Hietaharju, Aki, Sauranen, Jukka, Wirta, Ole
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - administration & dosage
Angiogenesis Inhibitors - adverse effects
Angiogenesis Inhibitors - therapeutic use
Biological and medical sciences
Diagnosis, Differential
Exanthema - chemically induced
Female
Hematologic and hematopoietic diseases
Humans
Medical sciences
Middle Aged
POEMS Syndrome - diagnosis
POEMS Syndrome - drug therapy
Thalidomide - administration & dosage
Thalidomide - adverse effects
Thalidomide - therapeutic use
Treatment Outcome
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Description
Summary:We report a patient with incapacitating POEMS syndrome characterized by serum monoclonal protein, polyneuropathy, organomegaly, endocrinopathy, mesangiocapillary glomerulonephritis, massive ascites formation, and pulmonary hypertension. A dramatic improvement in the clinical condition occurred after administration of thalidomide, a drug with known anti‐angiogenetic, anti‐proliferative, and anti‐cytokine properties. Am. J. Hematol. 76:66–68, 2004. © 2004 Wiley‐Liss, Inc.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.20051