Lack of association or linkage disequilibrium between schizophrenia and polymorphisms in the 5-HT1Dα and 5-HT1Dβ autoreceptor genes: Family-based association study

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2004-07, Vol.128B (1), p.1-5
• Main Authors: Ambrósio, Alda M., Kennedy, James L., Macciardi, Fabio, Coelho, Isabel, Soares, Maria J., Oliveira, Catarina R., Pato, Carlos N.
• Format: Article
• Language: English
• Subjects: candidate genes; haplotypes; Introduction; linkage disequilibrium; serotoninergic system
• ISSN: 1552-4841; 1552-485X
• DOI: 10.1002/ajmg.b.30023

Genetic factors play a major role in the etiology of schizophrenia and disturbances of serotonergic pathways have been implicated in this disorder. The aim of the present study was to examine genetic association between schizophrenia and polymorphisms in the 5‐HT1Dα (TaqI) and 5‐HT1Dβ (T261G and G861C) autoreceptor genes in ninety trios from Portugal. No association or linkage disequilibrium was obtained between schizophrenia and 5‐HT1Dα and 5‐HT1Dβ autoreceptor genes with both haplotype relative risk (HRR) and transmission disequilibrium test (TDT). Concerning 5‐HT1Dβ autoreceptor gene, also negative results was obtained in the analysis of the haplotypes with transmit. Thus, our data provide no support for the hypothesis that polymorphisms at 5‐HT1Dα (TaqI) and 5‐HT1Dβ (T261G and G861C) genes contributes to susceptibility to schizophrenia in the Portuguese population. © 2004 Wiley‐Liss, Inc.