Morbid risk for psychiatric disorder among the relatives of methamphetamine users with and without psychosis

It is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP‐induced psychosis (MIP) have greater familial loading for psychotic disorders than us...

Full description

Saved in:
Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2005-07, Vol.136B (1), p.87-91
Main Authors: Chen, Chih-Ken, Lin, Shih-Ku, Sham, Pak C., Ball, David, Loh, El-Wui, Murray, Robin M.
Format: Article
Language:English
Subjects:
Adult
amphetamine
Amphetamine-Related Disorders - epidemiology
Amphetamine-Related Disorders - genetics
Comorbidity
familial risk
Family
Female
genetic disposition
Humans
Interviews as Topic
Male
Mental Disorders - genetics
Methamphetamine - poisoning
Prevalence
psychosis
Psychotic Disorders - epidemiology
Psychotic Disorders - etiology
Risk Factors
schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
substance abuse
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is not clear why some methamphetamine (MAMP) abusers develop psychotic symptoms, while others use MAMP regularly over long periods and remain unscathed. We tested the hypotheses that those users who develop MAMP‐induced psychosis (MIP) have greater familial loading for psychotic disorders than users with no psychosis. Four hundred forty‐five MAMP users were recruited from a psychiatric hospital and a detention center in Taipei, and were assessed with the Diagnostic Interview for genetic studies (DIGS‐C) and the Family Interview for genetic study (FIGS‐C). Morbid risk (MR) for psychiatric disorders in first‐degree relatives was compared between those MAMP users with a lifetime diagnosis of MAMP psychosis and those without. The relatives of MAMP users with a lifetime diagnosis of MAMP psychosis had a significantly higher MR for schizophrenia (OR = 5.4, 95% CI: 2.0–14.7, P 
ISSN:1552-4841
1552-485X
DOI:10.1002/ajmg.b.30187