Metal‐, Oxidant‐, and Additive‐Free Sulfenylation of Imidazo[1,2‐a]pyridines Using Sulfenamides and an I 2 Catalyst

A novel sulfenylation reagent (sulfenamide) was applied to establish a simple and efficient process to convert C−H bond in imidazo[1,2‐ a ]pyridine to C−S bond. This process only requires sulfenamides as the sulfenylation reagent and I 2 as an inexpensive and readily available catalyst, without usin...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2023-08, Vol.12 (8)
Main Authors: Qiao, Huijie, Zhao, Kun, Zhu, Xilin, Xu, Xiaoxu, Wang, Chunyang, Zhong, Lulu, Wang, Shixing, Yang, Liting, Yang, Dehong, Liu, Guoqun, Lin, Chunlei, Jiao, Mingli
Format: Article
Language:English
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Summary:A novel sulfenylation reagent (sulfenamide) was applied to establish a simple and efficient process to convert C−H bond in imidazo[1,2‐ a ]pyridine to C−S bond. This process only requires sulfenamides as the sulfenylation reagent and I 2 as an inexpensive and readily available catalyst, without using metal catalysts, oxidants, additives, or even light radiation. The proposed reaction features excellent reactivity, substrate compatibility, and regioselectivity.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202300292