dP/dt max : An underestimated prognostic factor in large animal infarction model

The present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes. A 90-min closed-chest balloon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in Pannon minipi...

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Bibliographic Details
Published in:Animal models and experimental medicine 2024-11
Main Authors: Garamvölgyi, Rita, Kőrösi, Dénes, Tátrai, Ottó, Bodor, Emőke, Fajtai, Dániel, Farkas, Kornélia, Vorobcsuk, András
Format: Article
Language:English
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Summary:The present study aims to establish a reproducible large animal experimental unit using a minipig model to monitor cardiac function changes. A 90-min closed-chest balloon occlusion of the left anterior descending branch of the coronary artery was used to induce myocardial infarction in Pannon minipigs. To monitor the cardiac function, measurements were made by cardiac magnetic resonance imaging (cMRI), invasive pressure monitoring, and a Pulse index Continuous Cardiac Output (PiCCO) hemodynamic system at 0, 72, and 720 h during the follow-up period. End-diastolic and end-systolic volumes (EDV, ESV), left ventricular ejection fraction (LVEF) obtained by cMRI evaluation, global ejection fraction and aortic dP/dt obtained by the invasive method, were recorded and compared. The 72- and 720-h EDV data showed a significant increase (p = 0.012,
ISSN:2576-2095
2576-2095
DOI:10.1002/ame2.12502