Diastereomer Resolution of M 4 L 6 Coordination Cages by Ultra‐High‐Resolution Ion‐Mobility Mass Spectrometry

Coordination cages can be used for enantio‐ and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra‐high‐resolution cyclic ion‐mobility mass spectrometry (cIM‐MS). The observ...

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Bibliographic Details
Published in:Angewandte Chemie 2023-07, Vol.135 (27)
Main Authors: Pfrunder, Michael C., Marshall, David L., Poad, Berwyck L. J., Fulloon, Therese M., Clegg, Jack K., Blanksby, Stephen J., McMurtrie, John C., Mullen, Kathleen M.
Format: Article
Language:English
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Summary:Coordination cages can be used for enantio‐ and regioselective catalysis and for the selective sensing and separation of isomeric guest molecules. Here, stereoisomers of a family of coordination cages are resolved using ultra‐high‐resolution cyclic ion‐mobility mass spectrometry (cIM‐MS). The observed ratio of diastereomers is dependent on both the metal ion and counter ion. Moreover, the point groups can be assigned through complementary NMR experiments. This method enables the identification and interrogation of the individual isomers in complex mixtures of cages which cannot be performed in solution. Furthermore, these techniques allow the stability of individual isomers within the mixture to be probed, with the T ‐symmetric isomers in this case shown to be more robust than the C 3 and S 4 analogues.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.202302229