Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)

A synapse‐mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid‐tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confined within a nanopipette, as reported by Ru‐Jia Yu, Yi‐Tao Long...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie 2024-09, Vol.136 (39), p.n/a
Main Authors: Chen, Ke‐Le, Yu, Ru‐Jia, Zhong, Cheng‐Bing, Wang, Ziyi, Xie, Bao‐Kang, Ma, Hui, Ao, Mingjun, Zheng, Peng, Ewing, Andrew G., Long, Yi‐Tao
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page n/a
container_issue 39
container_start_page
container_title Angewandte Chemie
container_volume 136
creator Chen, Ke‐Le
Yu, Ru‐Jia
Zhong, Cheng‐Bing
Wang, Ziyi
Xie, Bao‐Kang
Ma, Hui
Ao, Mingjun
Zheng, Peng
Ewing, Andrew G.
Long, Yi‐Tao
description A synapse‐mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid‐tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confined within a nanopipette, as reported by Ru‐Jia Yu, Yi‐Tao Long et al. in their Communication (e202406677). Characteristic ionic current oscillations were recorded and could be used to evaluate the binding affinity of tau protein, indicating that phosphorylated tau inhibits vesicle dynamics through strong interactions with synaptic vesicles.
doi_str_mv 10.1002/ange.202414132
format article
fullrecord <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_ange_202414132</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ANGE202414132</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1292-b254aecc5a63086d45bbc604f05c02ad097da53b883203bf9a64140fab57dc423</originalsourceid><addsrcrecordid>eNqFkLtOw0AQRVcIJEKgpd4SCjuzLz_oIhNCpBCkKNBa6_U6LGzWke0ockdNxQfR8Sd8CY6CoKQaaXTPzNVB6JyATwDoQLql9ilQTjhh9AD1iKDEY6EID1EPgHMvojw-Rid1_QwAAQ3jHnqbf36ol8Y02mbG5ld4ZLVqqlI96ZVR0uK70pmmrIxb4rLAcy3t1-v7wqw0ftS1UVbj69bJLlvjics3Suc4a_FCbrBxWOKkdIVx3XImXbk2a900Gl8Mu6pbHyfdEx-zeLBrfXmKjgppa332M_vo4Wa0SG696f14kgynniI0pl5GBZdaKSEDBlGQc5FlKgBegFBAZQ5xmEvBsihiFFhWxDLojEAhMxHmilPWR_7-rqrKuq50ka4rs5JVmxJIdybTncn012QHxHtga6xu_0mnw9l49Md-A3hKeRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Chen, Ke‐Le ; Yu, Ru‐Jia ; Zhong, Cheng‐Bing ; Wang, Ziyi ; Xie, Bao‐Kang ; Ma, Hui ; Ao, Mingjun ; Zheng, Peng ; Ewing, Andrew G. ; Long, Yi‐Tao</creator><creatorcontrib>Chen, Ke‐Le ; Yu, Ru‐Jia ; Zhong, Cheng‐Bing ; Wang, Ziyi ; Xie, Bao‐Kang ; Ma, Hui ; Ao, Mingjun ; Zheng, Peng ; Ewing, Andrew G. ; Long, Yi‐Tao</creatorcontrib><description>A synapse‐mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid‐tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confined within a nanopipette, as reported by Ru‐Jia Yu, Yi‐Tao Long et al. in their Communication (e202406677). Characteristic ionic current oscillations were recorded and could be used to evaluate the binding affinity of tau protein, indicating that phosphorylated tau inhibits vesicle dynamics through strong interactions with synaptic vesicles.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.202414132</identifier><language>eng</language><ispartof>Angewandte Chemie, 2024-09, Vol.136 (39), p.n/a</ispartof><rights>2024 Wiley-VCH GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7371-8449 ; 0000-0003-2571-7457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Chen, Ke‐Le</creatorcontrib><creatorcontrib>Yu, Ru‐Jia</creatorcontrib><creatorcontrib>Zhong, Cheng‐Bing</creatorcontrib><creatorcontrib>Wang, Ziyi</creatorcontrib><creatorcontrib>Xie, Bao‐Kang</creatorcontrib><creatorcontrib>Ma, Hui</creatorcontrib><creatorcontrib>Ao, Mingjun</creatorcontrib><creatorcontrib>Zheng, Peng</creatorcontrib><creatorcontrib>Ewing, Andrew G.</creatorcontrib><creatorcontrib>Long, Yi‐Tao</creatorcontrib><title>Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)</title><title>Angewandte Chemie</title><description>A synapse‐mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid‐tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confined within a nanopipette, as reported by Ru‐Jia Yu, Yi‐Tao Long et al. in their Communication (e202406677). Characteristic ionic current oscillations were recorded and could be used to evaluate the binding affinity of tau protein, indicating that phosphorylated tau inhibits vesicle dynamics through strong interactions with synaptic vesicles.</description><issn>0044-8249</issn><issn>1521-3757</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOw0AQRVcIJEKgpd4SCjuzLz_oIhNCpBCkKNBa6_U6LGzWke0ockdNxQfR8Sd8CY6CoKQaaXTPzNVB6JyATwDoQLql9ilQTjhh9AD1iKDEY6EID1EPgHMvojw-Rid1_QwAAQ3jHnqbf36ol8Y02mbG5ld4ZLVqqlI96ZVR0uK70pmmrIxb4rLAcy3t1-v7wqw0ftS1UVbj69bJLlvjics3Suc4a_FCbrBxWOKkdIVx3XImXbk2a900Gl8Mu6pbHyfdEx-zeLBrfXmKjgppa332M_vo4Wa0SG696f14kgynniI0pl5GBZdaKSEDBlGQc5FlKgBegFBAZQ5xmEvBsihiFFhWxDLojEAhMxHmilPWR_7-rqrKuq50ka4rs5JVmxJIdybTncn012QHxHtga6xu_0mnw9l49Md-A3hKeRA</recordid><startdate>20240923</startdate><enddate>20240923</enddate><creator>Chen, Ke‐Le</creator><creator>Yu, Ru‐Jia</creator><creator>Zhong, Cheng‐Bing</creator><creator>Wang, Ziyi</creator><creator>Xie, Bao‐Kang</creator><creator>Ma, Hui</creator><creator>Ao, Mingjun</creator><creator>Zheng, Peng</creator><creator>Ewing, Andrew G.</creator><creator>Long, Yi‐Tao</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-7371-8449</orcidid><orcidid>https://orcid.org/0000-0003-2571-7457</orcidid></search><sort><creationdate>20240923</creationdate><title>Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)</title><author>Chen, Ke‐Le ; Yu, Ru‐Jia ; Zhong, Cheng‐Bing ; Wang, Ziyi ; Xie, Bao‐Kang ; Ma, Hui ; Ao, Mingjun ; Zheng, Peng ; Ewing, Andrew G. ; Long, Yi‐Tao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1292-b254aecc5a63086d45bbc604f05c02ad097da53b883203bf9a64140fab57dc423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ke‐Le</creatorcontrib><creatorcontrib>Yu, Ru‐Jia</creatorcontrib><creatorcontrib>Zhong, Cheng‐Bing</creatorcontrib><creatorcontrib>Wang, Ziyi</creatorcontrib><creatorcontrib>Xie, Bao‐Kang</creatorcontrib><creatorcontrib>Ma, Hui</creatorcontrib><creatorcontrib>Ao, Mingjun</creatorcontrib><creatorcontrib>Zheng, Peng</creatorcontrib><creatorcontrib>Ewing, Andrew G.</creatorcontrib><creatorcontrib>Long, Yi‐Tao</creatorcontrib><collection>CrossRef</collection><jtitle>Angewandte Chemie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ke‐Le</au><au>Yu, Ru‐Jia</au><au>Zhong, Cheng‐Bing</au><au>Wang, Ziyi</au><au>Xie, Bao‐Kang</au><au>Ma, Hui</au><au>Ao, Mingjun</au><au>Zheng, Peng</au><au>Ewing, Andrew G.</au><au>Long, Yi‐Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)</atitle><jtitle>Angewandte Chemie</jtitle><date>2024-09-23</date><risdate>2024</risdate><volume>136</volume><issue>39</issue><epage>n/a</epage><issn>0044-8249</issn><eissn>1521-3757</eissn><abstract>A synapse‐mimicking nanopipette method was developed to electrochemically monitor single vesicle dynamics induced by lipid‐tau interactions. To mimic the lipid environment in synapses, model vesicles and a modified lipid layer were confined within a nanopipette, as reported by Ru‐Jia Yu, Yi‐Tao Long et al. in their Communication (e202406677). Characteristic ionic current oscillations were recorded and could be used to evaluate the binding affinity of tau protein, indicating that phosphorylated tau inhibits vesicle dynamics through strong interactions with synaptic vesicles.</abstract><doi>10.1002/ange.202414132</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7371-8449</orcidid><orcidid>https://orcid.org/0000-0003-2571-7457</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0044-8249
ispartof Angewandte Chemie, 2024-09, Vol.136 (39), p.n/a
issn 0044-8249
1521-3757
language eng
recordid cdi_crossref_primary_10_1002_ange_202414132
source Wiley-Blackwell Read & Publish Collection
title Rücktitelbild: Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette (Angew. Chem. 39/2024)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A03%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=R%C3%BCcktitelbild:%20Electrochemical%20Monitoring%20of%20Real%E2%80%90Time%20Vesicle%20Dynamics%20Induced%20by%20Tau%20in%20a%20Confined%20Nanopipette%20(Angew.%20Chem.%2039/2024)&rft.jtitle=Angewandte%20Chemie&rft.au=Chen,%20Ke%E2%80%90Le&rft.date=2024-09-23&rft.volume=136&rft.issue=39&rft.epage=n/a&rft.issn=0044-8249&rft.eissn=1521-3757&rft_id=info:doi/10.1002/ange.202414132&rft_dat=%3Cwiley_cross%3EANGE202414132%3C/wiley_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c1292-b254aecc5a63086d45bbc604f05c02ad097da53b883203bf9a64140fab57dc423%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true