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Nontoxic Membrane-Active Antimicrobial Arylamide Oligomers

Cracking the case: Aryl amide oligomers with amphiphilic secondary structure were designed that attack bacteria by lysing their membranes. A variety of groups were appended to the lead compound to adjust its overall charge, hydrophobicity, and hydrophobic moment. An Arg‐containing oligomer (see figu...

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Published in:	Angewandte Chemie International Edition 2004-02, Vol.43 (9), p.1158-1162
Main Authors:	Liu, Dahui, Choi, Sungwook, Chen, Bin, Doerksen, Robert J., Clements, Dylan J., Winkler, Jeffrey D., Klein, Michael L., DeGrado, William F.
Format:	Article
Language:	English
Subjects:	Amides - chemistry Amides - pharmacology amphiphiles Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology antimicrobial agents aryl amides Escherichia coli - drug effects Hydrophobic and Hydrophilic Interactions Inhibitory Concentration 50 Membranes - metabolism Microbial Sensitivity Tests Models, Molecular Molecular Structure oligomers Peptides Staphylococcus aureus - drug effects Structure-Activity Relationship
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creator	Liu, Dahui Choi, Sungwook Chen, Bin Doerksen, Robert J. Clements, Dylan J. Winkler, Jeffrey D. Klein, Michael L. DeGrado, William F.
description	Cracking the case: Aryl amide oligomers with amphiphilic secondary structure were designed that attack bacteria by lysing their membranes. A variety of groups were appended to the lead compound to adjust its overall charge, hydrophobicity, and hydrophobic moment. An Arg‐containing oligomer (see figure) was found to have good antimicrobial activity and low toxicity towards human erythrocytes.
doi_str_mv	10.1002/anie.200352791
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source	Wiley-Blackwell Read & Publish Collection
subjects	Amides - chemistry Amides - pharmacology amphiphiles Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology antimicrobial agents aryl amides Escherichia coli - drug effects Hydrophobic and Hydrophilic Interactions Inhibitory Concentration 50 Membranes - metabolism Microbial Sensitivity Tests Models, Molecular Molecular Structure oligomers Peptides Staphylococcus aureus - drug effects Structure-Activity Relationship
title	Nontoxic Membrane-Active Antimicrobial Arylamide Oligomers
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