Cover Picture: Diastereoselective Temporary Silicon-Tethered Ring-Closing-Metathesis Reactions with Prochiral Alcohols: A New Approach to Long-Range Asymmetric Induction (Angew. Chem. Int. Ed. 15/2003)

Taking control of stereochemistry should lead to an enhanced understanding of the conformational aspects that affect diastereoselectivity in medium‐sized ring systems. The temporary silicon‐tethered ring‐closing‐metathesis reactions described by P. A. Evans et al. on page 1734 ff. represent a new st...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2003-04, Vol.42 (15), p.1671-1671
Main Authors: Evans, P. Andrew, Cui, Jian, Buffone, Gerald P.
Format: Article
Language:English
Subjects:
cyclization
diastereoselectivity
medium-sized rings
metathesis
silicon
Online Access:Get full text
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Summary:Taking control of stereochemistry should lead to an enhanced understanding of the conformational aspects that affect diastereoselectivity in medium‐sized ring systems. The temporary silicon‐tethered ring‐closing‐metathesis reactions described by P. A. Evans et al. on page 1734 ff. represent a new strategy for long‐range asymmetric induction that provides a useful approach to 1,4‐, 1,5‐, and 1,6‐stereocontrol.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200390379