Fast High-Resolution Protein Structure Determination by Using Unassigned NMR Data

The major bottleneck of rapid NMR‐based structure determination is data analysis. The solution to this problem is a method that enables automatic high‐resolution protein‐structure determination from unassigned, experimental NMR data without manual intervention in less than 24 h.

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2007-01, Vol.46 (7), p.1176-1179
Main Authors: Korukottu, Jegannath, Bayrhuber, Monika, Montaville, Pierre, Vijayan, Vinesh, Jung, Young-Sang, Becker, Stefan, Zweckstetter, Markus
Format: Article
Language:English
Subjects:
Algorithms
genomics
Models, Molecular
Mollusk Venoms - chemistry
Neurotoxins - chemistry
NMR spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Protein Conformation
Protein Folding
protein structures
Proteins - chemistry
structure elucidation
Ubiquitin - chemistry
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Description
Summary:The major bottleneck of rapid NMR‐based structure determination is data analysis. The solution to this problem is a method that enables automatic high‐resolution protein‐structure determination from unassigned, experimental NMR data without manual intervention in less than 24 h.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603213