Solid-Phase Library Synthesis of Polyynes Similar to Natural Products

High in polyunsaturates: The combinatorial synthesis of a 65‐membered polyyne library has been achieved by using an iterative acetylene homologation strategy combined with a solid support (see scheme). The library was evaluated against cancer cells to demonstrate its possible utility as a chemical t...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2007-01, Vol.46 (44), p.8422-8425
Main Authors: Lee, Seonwoo, Lee, Taeho, Lee, Yun Mi, Kim, Deukjoon, Kim, Sanghee
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Biotechnology - methods
Catalysis
Cell Line, Tumor
Chemistry - methods
Chemistry, Pharmaceutical - methods
Chromatography
Colonic Neoplasms - drug therapy
combinatorial chemistry
cross-coupling
Drug Design
Humans
Inhibitory Concentration 50
Metals - chemistry
Models, Chemical
natural products
Polyacetylenes - chemistry
polyynes
Protein Engineering - methods
Sodium Fluoride - chemistry
solid-phase synthesis
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Summary:High in polyunsaturates: The combinatorial synthesis of a 65‐membered polyyne library has been achieved by using an iterative acetylene homologation strategy combined with a solid support (see scheme). The library was evaluated against cancer cells to demonstrate its possible utility as a chemical tool to unravel cellular processes or as a platform for drug discovery and design.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200703208