Three-Coordinate Ligand for Physiological Beryllium Imaging by Fluoresence

To Be or not to Be: Be binds strongly to the three‐dentate ligand 2,6‐bis(2‐hydroxyphenyl)pyridine in a 1:1 ratio with no bridging phenolates (see structure; Be green, C gray, H white, O red, N blue). As Be binds and displaces the strong hydrogen bonds, the ligand fluoresces. The fluorescence is ver...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2008-09, Vol.47 (38), p.7332-7334
Main Authors: Diyabalanage, Himashinie V. K., Ganguly, Kumkum, Ehler, Deborah S., Collis, Gavin E., Scott, Brian L., Chaudhary, Anu, Burrell, Anthony K., McCleskey, T. Mark
Format: Article
Language:English
Subjects:
beryllium
fluorescent probes
immunology
ligand design
luminescence
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To Be or not to Be: Be binds strongly to the three‐dentate ligand 2,6‐bis(2‐hydroxyphenyl)pyridine in a 1:1 ratio with no bridging phenolates (see structure; Be green, C gray, H white, O red, N blue). As Be binds and displaces the strong hydrogen bonds, the ligand fluoresces. The fluorescence is very specific for Be and can be used to detect beryllium in cells, as demonstrated with human lung epithelial cells (see picture, right).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200801965