Nanoparticles with In Vivo Anticancer Activity from Polymer Prodrug Amphiphiles Prepared by Living Radical Polymerization

Magic rubber bullets: Novel anticancer nanoparticles made of well‐defined polymer–drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide‐mediated polymerization (NMP; see picture). The resulting conjugates se...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2013-02, Vol.52 (6), p.1678-1682
Main Authors: Harrisson, Simon, Nicolas, Julien, Maksimenko, Andrei, Bui, Duc Trung, Mougin, Julie, Couvreur, Patrick
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
cancer
Cell Line, Tumor
Deoxycytidine - administration & dosage
Deoxycytidine - analogs & derivatives
Deoxycytidine - chemistry
Drug Carriers - chemistry
drug delivery
Free Radicals - chemistry
Humans
Mice
Mice, Nude
nanoparticles
Nanoparticles - chemistry
Pancreatic Neoplasms - drug therapy
Polymerization
Polymers - chemistry
prodrugs
Prodrugs - administration & dosage
Prodrugs - chemistry
Transplantation, Heterologous
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Magic rubber bullets: Novel anticancer nanoparticles made of well‐defined polymer–drug conjugate amphiphiles are prepared by the controlled growth of a hydrophobic polyisoprene chain from a drug macroinitiator by using nitroxide‐mediated polymerization (NMP; see picture). The resulting conjugates self‐assembled into nanoparticles exhibiting high drug payloads and significant anticancer activities both in vitro and in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201207297