Crystallographic Snapshot of an Arrested Intermediate in the Biomimetic Activation of CO 2

The design of molecular catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biological systems. Herein, we report how the bulky arms of the cations in [( n C 4 H 9 ) 4 N] + [HCO 3 ] ‐ give rise to a host s...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2015-01, Vol.54 (1), p.164-168
Main Authors: Ackermann, Sarah L., Wolstenholme, David J., Frazee, Chris, Deslongchamps, Ghislain, Riley, Sandra H. M., Decken, Andreas, McGrady, G. Sean
Format: Article
Language:English
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Summary:The design of molecular catalysts that mimic the behavior of enzymes is a topical field of activity in emerging technologies, and can lead to an improved understanding of biological systems. Herein, we report how the bulky arms of the cations in [( n C 4 H 9 ) 4 N] + [HCO 3 ] ‐ give rise to a host scaffold that emulates the substrate binding sites in carbonic anhydrase enzymes, affording a unique glimpse of an arrested intermediate in the base‐mediated binding and activation of CO 2 .
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201407165