Crystal structure of a NIR-Emitting DNA-Stabilized Ag 16 Nanocluster

DNA has been used as a scaffold to stabilize small, atomically monodisperse silver nanoclusters, which have attracted attention due to their intriguing photophysical properties. Herein, we describe the X-ray crystal structure of a DNA-encapsulated, near-infrared emitting Ag nanocluster (DNA-Ag NC)....

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-11, Vol.58 (48), p.17153-17157
Main Authors: Cerretani, Cecilia, Kanazawa, Hiroki, Vosch, Tom, Kondo, Jiro
Format: Article
Language:English
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Summary:DNA has been used as a scaffold to stabilize small, atomically monodisperse silver nanoclusters, which have attracted attention due to their intriguing photophysical properties. Herein, we describe the X-ray crystal structure of a DNA-encapsulated, near-infrared emitting Ag nanocluster (DNA-Ag NC). The asymmetric unit of the crystal contains two DNA-Ag NCs and the crystal packing between the DNA-Ag NCs is promoted by several interactions, such as two silver-mediated base pairs between 3'-terminal adenines, two phosphate-Ca -phosphate interactions, and π-stacking between two neighboring thymines. Each Ag NC is confined by two DNA decamers that take on a horse-shoe-like conformation and is almost fully shielded from the solvent environment. This structural insight will aid in the determination of the structure/photophysical property relationship for this class of emitters and opens up new research opportunities in fluorescence imaging and sensing using noble-metal clusters.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201906766