Back Cover: Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles (Angew. Chem. Int. Ed. 27/2019)

Highly stable tetrazines that react rapidly with isonitriles are presented by R. M. Franzini et al. in their Communication on page 9043 ff. Bulky tetrazine substituents sterically attract the isocyano group in the cycloaddition transition state and block the approach of strained alkenes. These chara...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-07, Vol.58 (27), p.9290-9290
Main Authors: Tu, Julian, Svatunek, Dennis, Parvez, Saba, Liu, Albert C., Levandowski, Brian J., Eckvahl, Hannah J., Peterson, Randall T., Houk, Kendall N., Franzini, Raphael M.
Format: Article
Language:English
Subjects:
bioconjugation
bioorthogonal chemistry
chemoselectivity
cycloadditions
dispersion forces
Online Access:Get full text
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Summary:Highly stable tetrazines that react rapidly with isonitriles are presented by R. M. Franzini et al. in their Communication on page 9043 ff. Bulky tetrazine substituents sterically attract the isocyano group in the cycloaddition transition state and block the approach of strained alkenes. These characteristics enable rapid bioorthogonal labeling and release reactions and allow for triple‐orthogonal protein labeling.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201906875