Inside Cover: Molecular Bases for Anesthetic Agents: Halothane as a Halogen‐ and Hydrogen‐Bond Donor (Angew. Chem. Int. Ed. 36/2019)

Halothane, a commonly used anesthetic can simultaneously function as a hydrogen‐bond and a halogen‐bond donor in the solid state and in solution, as shown by S. V. Rosokha, G. Resnati, and co‐workers in their Communication on page 12456 ff. Both interactions involve moieties commonly present in cell...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-09, Vol.58 (36), p.12308-12308
Main Authors: Nayak, Susanta K., Terraneo, Giancarlo, Piacevoli, Quirino, Bertolotti, Federica, Scilabra, Patrick, Brown, John T., Rosokha, Sergiy V., Resnati, Giuseppe
Format: Article
Language:English
Subjects:
anesthetics
cryocrystallography
halogen bond
halothane
hydrogen bond
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Halothane, a commonly used anesthetic can simultaneously function as a hydrogen‐bond and a halogen‐bond donor in the solid state and in solution, as shown by S. V. Rosokha, G. Resnati, and co‐workers in their Communication on page 12456 ff. Both interactions involve moieties commonly present in cell membranes, probable target structures of halothane in the human body. The ability of the agent to act as a polydentate tecton gives a molecular rationale for its eudismic ratio.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201908842