Inside Back Cover: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. Int. Ed. 15/2020)

Highly selective fluorescent ligands derived from the opium poppy were developed by D. Calebiro, M. Decker et al. in their Research Article on page 5958 to investigate whether μ‐opioid receptors (μ‐ORs) can form dimers on the plasma membrane. These compounds exhibit long residence time and high affi...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-04, Vol.59 (15), p.6289-6289
Main Authors: Gentzsch, Christian, Seier, Kerstin, Drakopoulos, Antonios, Jobin, Marie‐Lise, Lanoiselée, Yann, Koszegi, Zsombor, Maurel, Damien, Sounier, Rémy, Hübner, Harald, Gmeiner, Peter, Granier, Sébastien, Calebiro, Davide, Decker, Michael
Format: Article
Language:English
Subjects:
fluorescent probes
G-protein coupled receptor
homodimerization
opioid ligands
single-molecule microscopy
Online Access:Get full text
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Summary:Highly selective fluorescent ligands derived from the opium poppy were developed by D. Calebiro, M. Decker et al. in their Research Article on page 5958 to investigate whether μ‐opioid receptors (μ‐ORs) can form dimers on the plasma membrane. These compounds exhibit long residence time and high affinity. Applying these chemical tools, single‐molecule microscopy allowed detection of a small fraction of short‐lived homodimers.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202002281