Back Cover: Novel Anthracycline Utorubicin for Cancer Therapy (Angew. Chem. Int. Ed. 31/2021)

A new anthracycline, utorubicin (UTO), with more potent anticancer activity than the clinically used doxorubicin was synthetized and encapsulated in polymeric nanovesicles (polymersomes) by Lorena Simón‐Gracia, Tambet Teesalu et al. in their Research Article on page 17018. The polymersomes were func...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2021-07, Vol.60 (31), p.17220-17220
Main Authors: Simón‐Gracia, Lorena, Sidorenko, Valeria, Uustare, Ain, Ogibalov, Ivan, Tasa, Andrus, Tshubrik, Olga, Teesalu, Tambet
Format: Article
Language:English
Subjects:
anthracycline
antitumor agents
polymersomes
targeted drug delivery
utorubicin
Online Access:Get full text
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Summary:A new anthracycline, utorubicin (UTO), with more potent anticancer activity than the clinically used doxorubicin was synthetized and encapsulated in polymeric nanovesicles (polymersomes) by Lorena Simón‐Gracia, Tambet Teesalu et al. in their Research Article on page 17018. The polymersomes were functionalized with tumor penetrating peptides (TPP) that specifically target cancer cells. In breast tumor mice, the TTP coating enhanced the tumor homing of the systemically administered UTO polymersomes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202106593