Inside Back Cover: Tuning the Elasticity of Nanogels Improves Their Circulation Time by Evading Immune Cells (Angew. Chem. Int. Ed. 20/2022)

Mechanical properties of nanogels influence their cellular fate. Inspired by the natural ability of the cells to sense stiffness, Smriti Singh et al. in their Research Article (e202116653) developed highly hydrophilic soft nanogels and show that the passive engulfment of the soft nanogels by the imm...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-05, Vol.61 (20), p.n/a
Main Authors: Desai, Prachi, Rimal, Rahul, Florea, Alexandru, Gumerov, Rustam A., Santi, Marta, Sorokina, Anastasia S., Sahnoun, Sabri E. M., Fischer, Thorsten, Mottaghy, Felix M., Morgenroth, Agnieszka, Mourran, Ahmed, Potemkin, Igor I., Möller, Martin, Singh, Smriti
Format: Article
Language:English
Subjects:
Biodistribution
Elasticity
Nanogels
Phagocytosis
Radiolabeling
Online Access:Get full text
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Summary:Mechanical properties of nanogels influence their cellular fate. Inspired by the natural ability of the cells to sense stiffness, Smriti Singh et al. in their Research Article (e202116653) developed highly hydrophilic soft nanogels and show that the passive engulfment of the soft nanogels by the immune cells was drastically reduced compared to the stiffer counterpart. The delayed uptake resulted in an enhanced circulation time of the nanogels, an important criterion for drug delivery applications.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202204930