Inside Back Cover: Expeditious Access to Morphinans by Chemical Synthesis (Angew. Chem. Int. Ed. 27/2022)

The morphinan alkaloids , especially codeine and morphine, are derived from the opium poppy and have been used for millennia for pain management. They remain vital medicines today, but climate change and geopolitical uncertainties threaten existing supply chains. In their Communication (e202203186),...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-07, Vol.61 (27), p.n/a
Main Authors: White, Lorenzo V., Hu, Nan, He, Yu‐Tao, Banwell, Martin G., Lan, Ping
Format: Article
Language:English
Subjects:
Alkaloids
Opiates
Palladium Catalysis
Photo-Redox Chemistry
Total Synthesis
Online Access:Get full text
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Summary:The morphinan alkaloids , especially codeine and morphine, are derived from the opium poppy and have been used for millennia for pain management. They remain vital medicines today, but climate change and geopolitical uncertainties threaten existing supply chains. In their Communication (e202203186), Martin G. Banwell, Ping Lan, and co‐workers detail by far the shortest synthesis of (−)‐codeine reported to date, which involves a total “in‐flask” time of less than 24 hours.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202207234