Back Cover: DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling (Angew. Chem. Int. Ed. 41/2022)

The fast and the furious: A computational DFT booster to accelerate cysteine bioconjugation: In their Research Article (202205348), Mu‐Hyun Baik, Christian P. R. Hackenberger, and co‐workers introduce ethynyl‐triazolyl‐phosphinates (ETPs) as modular electrophiles for the straightforward incorporatio...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2022-10, Vol.61 (41), p.n/a
Main Authors: Stieger, Christian E., Park, Yerin, Geus, Mark A. R., Kim, Dongju, Huhn, Christiane, Slenczka, J. Sophia, Ochtrop, Philipp, Müchler, Judith M., Süssmuth, Roderich D., Broichhagen, Johannes, Baik, Mu‐Hyun, Hackenberger, Christian P. R.
Format: Article
Language:English
Subjects:
Antibody-Drug-Conjugates
Bioconjugation
Cysteine Profiling
Protein-Based Electrophiles
Protein–Protein Conjugation
Online Access:Get full text
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Summary:The fast and the furious: A computational DFT booster to accelerate cysteine bioconjugation: In their Research Article (202205348), Mu‐Hyun Baik, Christian P. R. Hackenberger, and co‐workers introduce ethynyl‐triazolyl‐phosphinates (ETPs) as modular electrophiles for the straightforward incorporation into complex payloads and proteins for modular protein‐ and antibody‐modification strategies (cover picture: Barth van Rossum, FMP).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202212509