Highly Efficient Self‐Assembly of Heterometallic [2]Catenanes and Cyclic Bis[2]catenanes via Orthogonal Metal‐Coordination Interactions

• Published in: Angewandte Chemie International Edition 2024-08, Vol.63 (32), p.e202407923-n/a
• Main Authors: Feng, Qian, Ding, Rui, Hou, Yali, Zhang, Zeyuan, Zhang, Yafei, Liu, Haifei, Guo, Chenxing, He, Gang, Zheng, Bo, Zhang, Yanmin, Zhang, Mingming
• Format: Article
• Language: English
• Subjects: antibacterial activities; catenanes; cyclic biscatenanes; metal-coordination interactions; orthogonal self-assembly
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202407923

Although catenated cages have been widely constructed due to their unique and elegant topological structures, cyclic catenanes formed by the connection of multiple catenane units have been rarely reported. Herein, based on the orthogonal metal‐coordination‐driven self‐assembly, we prepare a series of heterometallic [2]catenanes and cyclic bis[2]catenanes, whose structures are clearly evidenced by single‐crystal X‐ray analysis. Owing to the multiple positively charged nature, as well as the potential synergistic effect of the Cu(I) and Pt(II) metal ions, the cyclic bis[2]catenanes display broad‐spectrum antibacterial activity. This work not only provides an efficient strategy for the construction of heterometallic [2]catenanes and cyclic bis[2]catenanes but also explores their applications as superior antibacterial agents, which will promote the construction of advanced supramolecular structures for biomedical applications. A series of heterometallic [2]catenanes and cyclic bis[2]catenanes were prepared efficiently via orthogonal metal‐coordination‐driven self‐assembly. Owing to the multiple positively charged nature, as well as the potential synergistic effect of the Cu(I) and Pt(II) metal ions, the cyclic bis[2]catenanes displayed broad‐spectrum antibacterial activity.