Synthesis and radioprotective study of new siladithioacetals and germadithioacetals

A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2‐[1‐(1‐naphthyl)ethyl]‐2‐imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organom...

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Bibliographic Details
Published in:Applied organometallic chemistry 2003-08, Vol.17 (8), p.561-569
Main Authors: Célariès, Benoît, Amourette, Christine, Lion, Claude, Rima, Ghassoub
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological effects of radiation
Chemistry
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
germadithioacetals
LD50
naphthylethylimidazoline
Organic chemistry
Organometalloidal and organometallic compounds
Preparations and properties
Radioprotection
radioprotective activity
Si derivatives
siladithioacetals
Tissues, organs and organisms biophysics
toxicity
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Summary:A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2‐[1‐(1‐naphthyl)ethyl]‐2‐imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organometallic derivatives have been found to possess radioprotective activity. We have also noted a notable decrease of the toxicity and a fairly large increase in the radioprotective activity in comparison with the unsubstituted organic molecules. Copyright © 2003 John Wiley & Sons, Ltd.
ISSN:0268-2605
1099-0739
DOI:10.1002/aoc.472