Collagen-based bioadhesive barnacle cement mimic I. Chemical and enzymatic studies

A biomedical adhesive that can bind to calcified tissues without drying and prior acid etch has been developed. The adhesive was prepared from commercially available gelatin, by first modifying its backbone to increase its phenolic content. This was achieved by reductive alkylation using phenolic al...

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Bibliographic Details
Published in:Die Angewandte makromolekulare Chemie 1987-11, Vol.155 (1), p.31-43
Main Authors: Kaleem, K., Chertok, F., Erhan, S.
Format: Article
Language:English
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Summary:A biomedical adhesive that can bind to calcified tissues without drying and prior acid etch has been developed. The adhesive was prepared from commercially available gelatin, by first modifying its backbone to increase its phenolic content. This was achieved by reductive alkylation using phenolic aldehydes. Gelatin, modified this way, functions as a substrate for polyphenol oxidase and crosslinking takes place. A concentrated solution of gelatin and the enzyme, together with amines, can bond bone slices. Ein biochemischer Kelbstoff 1st entwicket worden, der an kalzifizierten zGeweben ohne Trocknung and vorherige Säreätzung anklene kann. Die Vobereitung des Klebstoffs erfogle durch Modifiairung der Gelatine durch reduzierende Alkylierung mit phenolisen Aldehyden, um höhere Phenolgehalte zu erzielen. Die modifizirten Gelatine werden von Polyphenoloxide angegriffen, wobei vernetzung stattfindet. Eine konzentrierte Lösung von Gelatine, Enzym and verschiedenen Aminen 1st in der large, knochenstücke zusammenzukleben.
ISSN:0003-3146
1522-9505
DOI:10.1002/apmc.1987.051550103