Preparation and anticoagulant property of phosphorylcholine-terminated o-benzoylchitosan derivative

To improve the solubility in organic solvent of chitosan, o‐benzoylchitosan was synthesized by acylation with benzoyl chloride and then used in the reaction with 2‐chloro‐1,3,2‐dioxaphosphospholane (COP) to prepare phosphorylcholine‐terminated o‐benzoylchitosan (PC‐BCS). PC‐BCS had a structure with...

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Bibliographic Details
Published in:Journal of applied polymer science 2003-04, Vol.88 (2), p.489-493
Main Authors: Zhu, Aiping, Zhang, Jun, Shen, Jian
Format: Article
Language:English
Subjects:
anticoagulant property
Applied sciences
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
chitosan
Exact sciences and technology
Medical sciences
o-benzoylchitosan
Organic polymers
Pharmacology. Drug treatments
phosphorycholine
Physicochemistry of polymers
Properties and characterization
Thermal and thermodynamic properties
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Summary:To improve the solubility in organic solvent of chitosan, o‐benzoylchitosan was synthesized by acylation with benzoyl chloride and then used in the reaction with 2‐chloro‐1,3,2‐dioxaphosphospholane (COP) to prepare phosphorylcholine‐terminated o‐benzoylchitosan (PC‐BCS). PC‐BCS had a structure with a phospholipid polar group characterized by FTIR and 1H NMR. PC‐BCS had been polysubstituted by a PC group, which made PC‐BCS viscous liquid. The anticoagulant properties of PC‐BCS were evaluated by means of blood‐clotting and platelet adhesion assay. The blood‐clotting assay indicated that PC‐BCS could prolong the blood‐clotting process. Platelet adhesion assay showed that PC‐BCS could effectively inhibit the platelet adhesion and activation. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 88: 489–493, 2003
ISSN:0021-8995
1097-4628
DOI:10.1002/app.11755