Swelling and diffusion studies of poly(N-isopropylacrylamide/itaconic acid) copolymeric hydrogels in water and aqueous solutions of drugs

N‐Isopropylacrylamide/itaconic acid hydrogels (NIPAAm/IA) containing different amounts of itaconic acid prepared by irradiating with γ‐radiation were used in experiments on swelling and diffusion of the model drugs methylene blue, lidocaine, and sildenafil citrate (VIAGRA). The NIPAAm/IA hydrogels c...

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Bibliographic Details
Published in:Journal of applied polymer science 2004-01, Vol.91 (2), p.911-915
Main Authors: Taşdelen, Betül, Kayaman-Apohan, Nilhan, Güven, Olgun, Baysal, Bahattin M.
Format: Article
Language:English
Subjects:
Applied sciences
diffusion
Exact sciences and technology
hydrogels
Physicochemistry of polymers
Polymer industry, paints, wood
radiation
Technology of polymers
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Summary:N‐Isopropylacrylamide/itaconic acid hydrogels (NIPAAm/IA) containing different amounts of itaconic acid prepared by irradiating with γ‐radiation were used in experiments on swelling and diffusion of the model drugs methylene blue, lidocaine, and sildenafil citrate (VIAGRA). The NIPAAm/IA hydrogels containing 0–3 mol % itaconic acid irradiated at 48 kGy has been used for swelling and diffusion studies in water and aqueous solutions containing the above‐mentioned model drugs. For these hydrogels, swelling studies indicated that swelling increased with the following order: water > lidocaine > methylene blue > VIAGRA. Diffusions of water and the drugs within hydrogels were found to be non‐Fickian in character. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 91: 911–915, 2004
ISSN:0021-8995
1097-4628
DOI:10.1002/app.13223