Dietary TiO 2 particles modulate expression of hormone-related genes in Bombyx mori

Silkworm (Bombyx mori) is an economically beneficial insect. Its growth and development are regulated by endogenous hormones. In the present study, we found that feeding titanium dioxide nanoparticles (TiO NP) caused a significant increase of body size. TiO NP stimulated the transcription of several...

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Bibliographic Details
Published in:Archives of insect biochemistry and physiology 2017-08, Vol.95 (4)
Main Authors: Shi, Guofang, Zhan, Pengfei, Jin, Weiming, Fei, JianMing, Zhao, Lihua
Format: Article
Language:English
Subjects:
Animals
Bombyx - drug effects
Bombyx - genetics
Bombyx - metabolism
Gene Expression Profiling
Gene Expression Regulation - drug effects
Genes, Insect
Insect Hormones - metabolism
Nanoparticles
Titanium - pharmacology
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Summary:Silkworm (Bombyx mori) is an economically beneficial insect. Its growth and development are regulated by endogenous hormones. In the present study, we found that feeding titanium dioxide nanoparticles (TiO NP) caused a significant increase of body size. TiO NP stimulated the transcription of several genes, including the insulin-related hormone bombyxin, PI3K/Akt/TOR (where PI3K is phosphatidylinositol 3-kinase and TOR is target of rapamycin), and the adenosine 5'-monophosphateactivated protein kinase (AMPK)/target of rapamycin (TOR) pathways. Differentially expressed gene (DEG) analysis documented 26 developmental hormone signaling related genes that were differentially expressed following dietary TiO NP treatment. qPCR analysis confirmed the upregulation of insulin/ecdysteroid signaling genes, such as bombyxin B-1, bombyxin B-4, bombyxin B-7, MAPK, P70S6K, PI3k, eIF4E, E75, ecdysteroid receptor (EcR), and insulin-related peptide binding protein precursor 2 (IBP2). We infer from the upregulated expression of bombyxins and the signaling network that they act in bombyxin-stimulated ecdysteroidogenesis.
ISSN:0739-4462
1520-6327
DOI:10.1002/arch.21397