Synthesis of 1 H ‐Pyrazole‐1‐carboxamide Derivatives and Their Antiproliferative Activity against Melanoma Cell Line

Synthesis of a new series of 1 H ‐pyrazole‐1‐carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the...

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Bibliographic Details
Published in:Archiv der Pharmazie (Weinheim) 2011-03, Vol.344 (3), p.197-204
Main Authors: El‐Gamal, Mohammed I., Sim, Tae Bo, Hong, Jun Hee, Cho, Jung‐Hyuck, Yoo, Kyung Ho, Oh, Chang‐Hyun
Format: Article
Language:English
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Summary:Synthesis of a new series of 1 H ‐pyrazole‐1‐carboxamide derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the newly synthesized compounds showed moderate activity against A375, compared with sorafenib. Among all of these derivatives, compound IIe which has N‐ methylpiperazinyl and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.201000057