Fibrous myopathy. A rheumatic complication of drug abuse

A progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, afte...

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Bibliographic Details
Published in:Arthritis and rheumatism 1976-09, Vol.19 (5), p.923-926
Main Authors: Johnson, Kent R., Hsueh, Willa A., Glusman, Sheldon M., Arnett, Frank C.
Format: Article
Language:English
Subjects:
Biopsy
Contracture - etiology
Diazepam
Drug Combinations
Humans
Injections, Intramuscular - adverse effects
Male
Meperidine
Middle Aged
Muscles - pathology
Muscular Diseases - etiology
Muscular Diseases - pathology
Myography
Substance-Related Disorders - complications
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Summary:A progressive fibrous myopathy may result from chronic intramuscular drug abuse. This complication may mimic other rheumatic disorders and early recognition may prevent disability. The patient described here presented with fixed flexion and extension contracture of hips and knees, respectively, after abusing meperidine and other agents for 3 years. Soft tissues of thighs and buttocks were “wood hard,” EMG showed absence of action potentials in affected muscles, and biopsy revealed extensive replacement of muscle with dense, acellular fibrous tissue. Possible mechanisms are discussed.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780190514