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Lymphocyte Antigens in Neuropsychiatric Systemic Lupus Erythematosus

Objective. To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with SL...

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Published in:Arthritis and rheumatism 1994-03, Vol.37 (3), p.369-375
Main Authors: Denburg, Susan D., Behmann, Sharon A., Carbotte, Ramona M., Denburg, Judah A.
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Language:English
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container_title Arthritis and rheumatism
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creator Denburg, Susan D.
Behmann, Sharon A.
Carbotte, Ramona M.
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description Objective. To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with SLE were examined for the presence of IgM‐ and IgG‐class auto‐antibodies binding to surface target antigens on lymphocytes, by immunoblotting and microdroplet lymphocytotoxicity studies. Seventy‐three of these patients also underwent detailed neuropsychological testing within the same time period. Results. Significant associations were found between reactivities to several lymphocyte antigenic moieties and neuropsychiatric SLE (NPSLE) or cognitive impairment. Specifically, immunoblot reactivities to 31–32‐kd, 50–52‐kd, 54–56‐kd, and 97–98‐kd targets were associated with clinical NPSLE; there was a significant association between reactivity to the 50–52‐kd moiety in particular and cognitive impairment. There were also associations between LCA and immunoblot reactivity. Furthermore, the previously reported association between LCA positivity and specific visuospatial cognitive impairment was confirmed with data obtained from 2 different batteries of neuropsychological tests. Conclusion. In some cases, specific antigenic targets of LCA‐containing sera may be implicated in the pathogenesis of NPSLE.
doi_str_mv 10.1002/art.1780370310
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To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with SLE were examined for the presence of IgM‐ and IgG‐class auto‐antibodies binding to surface target antigens on lymphocytes, by immunoblotting and microdroplet lymphocytotoxicity studies. Seventy‐three of these patients also underwent detailed neuropsychological testing within the same time period. Results. Significant associations were found between reactivities to several lymphocyte antigenic moieties and neuropsychiatric SLE (NPSLE) or cognitive impairment. Specifically, immunoblot reactivities to 31–32‐kd, 50–52‐kd, 54–56‐kd, and 97–98‐kd targets were associated with clinical NPSLE; there was a significant association between reactivity to the 50–52‐kd moiety in particular and cognitive impairment. There were also associations between LCA and immunoblot reactivity. Furthermore, the previously reported association between LCA positivity and specific visuospatial cognitive impairment was confirmed with data obtained from 2 different batteries of neuropsychological tests. Conclusion. In some cases, specific antigenic targets of LCA‐containing sera may be implicated in the pathogenesis of NPSLE.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780370310</identifier><language>eng</language><publisher>New York: John Wiley &amp; Sons, Inc</publisher><ispartof>Arthritis and rheumatism, 1994-03, Vol.37 (3), p.369-375</ispartof><rights>Copyright © 1994 American College of Rheumatology</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2310-80b87d5e4c7fa41082c901ce24fdeec76b790cb20ae518a512ee620a83cb0c313</citedby><cites>FETCH-LOGICAL-c2310-80b87d5e4c7fa41082c901ce24fdeec76b790cb20ae518a512ee620a83cb0c313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780370310$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780370310$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27924,27925,46049,46473</link.rule.ids></links><search><creatorcontrib>Denburg, Susan D.</creatorcontrib><creatorcontrib>Behmann, Sharon A.</creatorcontrib><creatorcontrib>Carbotte, Ramona M.</creatorcontrib><creatorcontrib>Denburg, Judah A.</creatorcontrib><title>Lymphocyte Antigens in Neuropsychiatric Systemic Lupus Erythematosus</title><title>Arthritis and rheumatism</title><description>Objective. To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with SLE were examined for the presence of IgM‐ and IgG‐class auto‐antibodies binding to surface target antigens on lymphocytes, by immunoblotting and microdroplet lymphocytotoxicity studies. Seventy‐three of these patients also underwent detailed neuropsychological testing within the same time period. Results. Significant associations were found between reactivities to several lymphocyte antigenic moieties and neuropsychiatric SLE (NPSLE) or cognitive impairment. Specifically, immunoblot reactivities to 31–32‐kd, 50–52‐kd, 54–56‐kd, and 97–98‐kd targets were associated with clinical NPSLE; there was a significant association between reactivity to the 50–52‐kd moiety in particular and cognitive impairment. There were also associations between LCA and immunoblot reactivity. Furthermore, the previously reported association between LCA positivity and specific visuospatial cognitive impairment was confirmed with data obtained from 2 different batteries of neuropsychological tests. Conclusion. 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To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment. Methods. Sera from 115 patients with SLE were examined for the presence of IgM‐ and IgG‐class auto‐antibodies binding to surface target antigens on lymphocytes, by immunoblotting and microdroplet lymphocytotoxicity studies. Seventy‐three of these patients also underwent detailed neuropsychological testing within the same time period. Results. Significant associations were found between reactivities to several lymphocyte antigenic moieties and neuropsychiatric SLE (NPSLE) or cognitive impairment. Specifically, immunoblot reactivities to 31–32‐kd, 50–52‐kd, 54–56‐kd, and 97–98‐kd targets were associated with clinical NPSLE; there was a significant association between reactivity to the 50–52‐kd moiety in particular and cognitive impairment. There were also associations between LCA and immunoblot reactivity. Furthermore, the previously reported association between LCA positivity and specific visuospatial cognitive impairment was confirmed with data obtained from 2 different batteries of neuropsychological tests. Conclusion. In some cases, specific antigenic targets of LCA‐containing sera may be implicated in the pathogenesis of NPSLE.</abstract><cop>New York</cop><pub>John Wiley &amp; Sons, Inc</pub><doi>10.1002/art.1780370310</doi><tpages>7</tpages></addata></record>
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title Lymphocyte Antigens in Neuropsychiatric Systemic Lupus Erythematosus
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