Drug Binding and Delivery with Supramolecular System Based on Sodium Carboxymethylcellulose and Viologen Calix[4]resorcinol

In the present work, a simple supramolecular approach was used to spontaneously form nanoparticles from sodium carboxymethylcellulose and viologen calix[4]resorcinol as a result of joint self‐assembly in water at room temperature. Supramolecular interactions between them led to the formation of nano...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2024-12, Vol.19 (24), p.e202400709-n/a
Main Authors: Razuvayeva, Yuliya, Kashapov, Ruslan, Ziganshina, Albina, Salnikov, Vadim, Sapunova, Anastasiia, Voloshina, Alexandra, Zakharova, Lucia
Format: Article
Language:English
Subjects:
Calixarene
Calixarenes - chemistry
Carboxymethylcellulose Sodium - chemistry
Doxorubicin - chemistry
Drug Carriers - chemistry
Humans
Nanoparticles - chemistry
Non-covalent interaction
Quercetin - chemistry
Resorcinarene
Resorcinols - chemistry
Self-aggregation
Solubilization
Viologens - chemistry
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Summary:In the present work, a simple supramolecular approach was used to spontaneously form nanoparticles from sodium carboxymethylcellulose and viologen calix[4]resorcinol as a result of joint self‐assembly in water at room temperature. Supramolecular interactions between them led to the formation of nanoparticles, the morphology and properties of which depend on polymer/macrocycle ratio. When there is excess of macrocycle, the nanoparticles bind lipophilic oleic acid, and when there is excess of polymer, they bind hydrophilic doxorubicin. Interestingly, the solubilization of lipophilic quercetin into these nanoparticles was significantly increased compared to the pure polymer and macrocycle, regardless of their ratio. The nanoparticles of triple composition (polymer/macrocycle/drug) have a more effective penetration ability in tumorcells than those of double composition (polymer/drug). The presented results are the first step towards the creation of new nanotechnologies to improve the bioavailability and delivery of bioactive components. Supramolecular self‐assembly of sodium carboxymethylcellulose and viologen calix[4]resorcinol allows the creation of nanoparticles that can increase the aqueous solubility of hydrophobic drugs and the delivery of hydrophilic drugs to tumor cells.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202400709