Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma

BACKGROUND Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically. CASE In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome ar...

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Bibliographic Details
Published in:Birth defects research. A Clinical and molecular teratology 2005-08, Vol.73 (8), p.572-576
Main Authors: Miliaras, Dimosthenis, Grimbizis, Grigoris, Conroy, Jeffrey, Psarra, Natasha, Miliaras, Spyros, Nowak, Norma, Bontis, John
Format: Article
Language:English
Subjects:
Adult
bacterial artificial chromosome arrays
Biological and medical sciences
cervical teratoma
Chromosome Aberrations
Chromosomes, Human - genetics
comparative genomic hybridization
congenital teratoma
cytogenetics
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Humans
immature teratoma
In Situ Hybridization, Fluorescence
Karyotyping
Pregnancy
Pregnancy Complications, Neoplastic - pathology
Teratology. Teratogens
Teratoma - congenital
Teratoma - genetics
Teratoma - pathology
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Summary:BACKGROUND Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically. CASE In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1‐copy gain of 17q21.33. CONCLUSIONS None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1542-0752
1542-0760
DOI:10.1002/bdra.20152