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Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma
BACKGROUND Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically. CASE In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome ar...
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| Published in: | Birth defects research. A Clinical and molecular teratology 2005-08, Vol.73 (8), p.572-576 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3572-b17793120e561d68b6b040a914b0f5b0da0e2b9316fda9721ce86a822b3f54a23 |
| container_end_page | 576 |
| container_issue | 8 |
| container_start_page | 572 |
| container_title | Birth defects research. A Clinical and molecular teratology |
| container_volume | 73 |
| creator | Miliaras, Dimosthenis Grimbizis, Grigoris Conroy, Jeffrey Psarra, Natasha Miliaras, Spyros Nowak, Norma Bontis, John |
| description | BACKGROUND
Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically.
CASE
In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1‐copy gain of 17q21.33.
CONCLUSIONS
None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/bdra.20152 |
| format | article |
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Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically.
CASE
In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1‐copy gain of 17q21.33.
CONCLUSIONS
None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 1542-0752</identifier><identifier>EISSN: 1542-0760</identifier><identifier>DOI: 10.1002/bdra.20152</identifier><identifier>PMID: 16001440</identifier><identifier>CODEN: BDRPBT</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; bacterial artificial chromosome arrays ; Biological and medical sciences ; cervical teratoma ; Chromosome Aberrations ; Chromosomes, Human - genetics ; comparative genomic hybridization ; congenital teratoma ; cytogenetics ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; immature teratoma ; In Situ Hybridization, Fluorescence ; Karyotyping ; Pregnancy ; Pregnancy Complications, Neoplastic - pathology ; Teratology. Teratogens ; Teratoma - congenital ; Teratoma - genetics ; Teratoma - pathology</subject><ispartof>Birth defects research. A Clinical and molecular teratology, 2005-08, Vol.73 (8), p.572-576</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3572-b17793120e561d68b6b040a914b0f5b0da0e2b9316fda9721ce86a822b3f54a23</citedby><cites>FETCH-LOGICAL-c3572-b17793120e561d68b6b040a914b0f5b0da0e2b9316fda9721ce86a822b3f54a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17036689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16001440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miliaras, Dimosthenis</creatorcontrib><creatorcontrib>Grimbizis, Grigoris</creatorcontrib><creatorcontrib>Conroy, Jeffrey</creatorcontrib><creatorcontrib>Psarra, Natasha</creatorcontrib><creatorcontrib>Miliaras, Spyros</creatorcontrib><creatorcontrib>Nowak, Norma</creatorcontrib><creatorcontrib>Bontis, John</creatorcontrib><title>Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma</title><title>Birth defects research. A Clinical and molecular teratology</title><addtitle>Birth Defects Res A Clin Mol Teratol</addtitle><description>BACKGROUND
Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically.
CASE
In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1‐copy gain of 17q21.33.
CONCLUSIONS
None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>bacterial artificial chromosome arrays</subject><subject>Biological and medical sciences</subject><subject>cervical teratoma</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human - genetics</subject><subject>comparative genomic hybridization</subject><subject>congenital teratoma</subject><subject>cytogenetics</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>immature teratoma</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Karyotyping</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - pathology</subject><subject>Teratology. Teratogens</subject><subject>Teratoma - congenital</subject><subject>Teratoma - genetics</subject><subject>Teratoma - pathology</subject><issn>1542-0752</issn><issn>1542-0760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp90E1LAzEQBuAgiq0fF3-A5OJFqE6yu0l7rPUTioLoeZlkZ220u1uSbWX99UZb7M1ThvDwDvMydiLgQgDIS1N4vJAgMrnD-iJL5QC0gt2_OZM9dhDCe7SJ1nqf9YQCEGkKfdY9Niua8w_0XdN2C2e5nWH9RoEX1JJtqeCm47apFuixdSvib1Q3VXSzznhXuK_429Tc1Ry5xUC8KSOPCbVrcc4t-ZWzcXBVhe3SE28pBjUVHrG9EueBjjfvIXu9vXmZ3A-mT3cPk_F0YJNMy4ERWo8SIYEyJQo1NMpACjgSqYEyM1AgkDRRqLLAkZbC0lDhUEqTlFmKMjlk5-tc65sQPJX5wrsq3psLyH_6y3_6y3_7i_h0jRdLU1GxpZvCIjjbAAzxrNJjbV3YOg2JUsNRdGLtPt2cun9W5lfXz-P18m-4zomM</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Miliaras, Dimosthenis</creator><creator>Grimbizis, Grigoris</creator><creator>Conroy, Jeffrey</creator><creator>Psarra, Natasha</creator><creator>Miliaras, Spyros</creator><creator>Nowak, Norma</creator><creator>Bontis, John</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200508</creationdate><title>Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma</title><author>Miliaras, Dimosthenis ; Grimbizis, Grigoris ; Conroy, Jeffrey ; Psarra, Natasha ; Miliaras, Spyros ; Nowak, Norma ; Bontis, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3572-b17793120e561d68b6b040a914b0f5b0da0e2b9316fda9721ce86a822b3f54a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>bacterial artificial chromosome arrays</topic><topic>Biological and medical sciences</topic><topic>cervical teratoma</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human - genetics</topic><topic>comparative genomic hybridization</topic><topic>congenital teratoma</topic><topic>cytogenetics</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>immature teratoma</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Karyotyping</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic - pathology</topic><topic>Teratology. Teratogens</topic><topic>Teratoma - congenital</topic><topic>Teratoma - genetics</topic><topic>Teratoma - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miliaras, Dimosthenis</creatorcontrib><creatorcontrib>Grimbizis, Grigoris</creatorcontrib><creatorcontrib>Conroy, Jeffrey</creatorcontrib><creatorcontrib>Psarra, Natasha</creatorcontrib><creatorcontrib>Miliaras, Spyros</creatorcontrib><creatorcontrib>Nowak, Norma</creatorcontrib><creatorcontrib>Bontis, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miliaras, Dimosthenis</au><au>Grimbizis, Grigoris</au><au>Conroy, Jeffrey</au><au>Psarra, Natasha</au><au>Miliaras, Spyros</au><au>Nowak, Norma</au><au>Bontis, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma</atitle><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle><addtitle>Birth Defects Res A Clin Mol Teratol</addtitle><date>2005-08</date><risdate>2005</risdate><volume>73</volume><issue>8</issue><spage>572</spage><epage>576</epage><pages>572-576</pages><issn>1542-0752</issn><eissn>1542-0760</eissn><coden>BDRPBT</coden><abstract>BACKGROUND
Cervical immature teratoma is a rare congenital tumor, and very few cases have been studied cytogenetically.
CASE
In this article, we describe a case of this tumor type and present the findings of the karyotype of the lesion, which was performed with the bacterial artificial chromosome arrays using the comparative genomic hybridization method. The chromosomal abnormalities that we found included an amplification on 1p21.1, a 9p22 deletion, and a 1‐copy gain of 17q21.33.
CONCLUSIONS
None of the identified chromosomal aberrations have been previously associated with congenital extragonadal teratomas. Important genes that lie in these DNA regions may be implicated in the pathogenesis of congenital teratomas. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16001440</pmid><doi>10.1002/bdra.20152</doi><tpages>5</tpages></addata></record> |
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| ispartof | Birth defects research. A Clinical and molecular teratology, 2005-08, Vol.73 (8), p.572-576 |
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| language | eng |
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| source | Wiley |
| subjects | Adult bacterial artificial chromosome arrays Biological and medical sciences cervical teratoma Chromosome Aberrations Chromosomes, Human - genetics comparative genomic hybridization congenital teratoma cytogenetics Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans immature teratoma In Situ Hybridization, Fluorescence Karyotyping Pregnancy Pregnancy Complications, Neoplastic - pathology Teratology. Teratogens Teratoma - congenital Teratoma - genetics Teratoma - pathology |
| title | Novel karyotypic changes detected by comparative genomic hybridization in a case of congenital cervical immature teratoma |
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