Serum coenzyme Q 10 concentrations in healthy men supplemented with 30 mg or 100 mg coenzyme Q 10 for two months in a randomised controlled study

• Published in: BioFactors (Oxford) 2003-01, Vol.18 (1-4), p.185-193
• Main Authors: Zita, Čestmír, Overvad, Kim, Mortensen, Svend Aage, Sindberg, Christian Dan, Moesgaard, Sven, Hunter, Douglas A.
• Format: Article
• Language: English
• ISSN: 0951-6433; 1872-8081
• DOI: 10.1002/biof.5520180221

Serum coenzyme Q 10 (Q 10 ) concentrations were evaluated in healthy male volunteers supplemented with 30 mg or 100 mg Q 10 or placebo as a single daily dose for two months in a randomised, double‐blind, placebo‐controlled study. Median baseline serum Q 10 concentration in 99 men was 1.26 mg/l (10%, 90% fractiles: 0.82, 1.83). Baseline serum Q 10 concentration did not depend on age, while borderline significant positive associations were found for body weight and smoking 1–10 cigarettes/d. Supplementation with 30 mg or 100 mg Q 10 resulted in median increases in serum Q 10 concentration of 0.55 mg/l and 1.36 mg/l, respectively, compared with a median decrease of 0.23 mg/l with placebo. The changes in the Q 10 groups were significantly different from that in the placebo group, and the increase in the 100 mg Q 10 group was significantly greater than that in the 30∼mg Q 10 group. The change in serum Q 10 concentration in the Q 10 groups did not depend on baseline serum 10 concentration, age, or body weight.