Date seed oil limit oxidative injuries induced by hydrogen peroxide in human skin organ culture

The skin is chronically exposed to pro‐oxidant agents, leading to the generation of reactive oxygen species (ROS). To protect the skin against an over‐load of oxidant species, we studied the chemoprotective effect of one new natural product: “date seed oil: DSO”. This oil may serve as a potential so...

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Bibliographic Details
Published in:BioFactors (Oxford) 2007, Vol.29 (2-3), p.137-145
Main Authors: Dammak, Ines, Abdallah, Fatma Ben, Boudaya, Sonia, Besbes, Souhail, Keskes, Leila, Gaied, Amel El, Turki, Hamida, Attia, Hammadi, Hentati, Basma
Format: Article
Language:English
Subjects:
Adult
Antioxidants - therapeutic use
Date seed oil
human skin
Humans
Hydrogen Peroxide
Magnoliopsida - chemistry
Melanins - metabolism
Olive Oil
organ culture
Organ Culture Techniques
oxidative stress
Plant Oils - therapeutic use
Seeds - chemistry
Skin - injuries
Skin - metabolism
Skin Diseases - chemically induced
Skin Diseases - drug therapy
Skin Diseases - prevention & control
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Summary:The skin is chronically exposed to pro‐oxidant agents, leading to the generation of reactive oxygen species (ROS). To protect the skin against an over‐load of oxidant species, we studied the chemoprotective effect of one new natural product: “date seed oil: DSO”. This oil may serve as a potential source of natural antioxidants such as phenols and tocopherols. Here, the antioxidative potential of DSO was compared that of to extra virgin olive oil. Adult human skin was maintained in organ culture in the presence of the DSO and extra virgin olive oil before the addition of hydrogen peroxide (H2O2 ), in order to prevent the tissue from its oxidizing effects. Skin specimens were collected for histology and for melanin studies. In the investigated model system, DSO protects skin against oxidative injuries. It has a significant chemoprotective effect, by inhibition of damage caused by H2O2 compared with specimens without such addition endowing with a radical scavenging ability. The various components from DSO were much more potent antioxidant and more free radical scavengers of the H2O2 than those of olive oil. Our study shows that topical DSO treatment of the skin stimulates events in the epidermis leading to repair skin damage possibly due to antioxidant synergisms.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.552029204