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Technologies and strategies to characterize and quantitate metabolites in drug discovery and development
ABSTRACT Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for...
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| Published in: | Biomedical chromatography 2014-11, Vol.28 (11), p.1547-1553 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4299-1b269386560e4b1bd76ccd7b09413b52c293b96c6b167ad908e89ff6910c9c5a3 |
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| cites | cdi_FETCH-LOGICAL-c4299-1b269386560e4b1bd76ccd7b09413b52c293b96c6b167ad908e89ff6910c9c5a3 |
| container_end_page | 1553 |
| container_issue | 11 |
| container_start_page | 1547 |
| container_title | Biomedical chromatography |
| container_volume | 28 |
| creator | Ravindran, Selvan Jadhav, Amol Surve, Prashant Lonsane, Ganesh Honrao, Pradnya Nanda, Bidyut |
| description | ABSTRACT
Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for the routine analysis of drugs and metabolites in the drug discovery set‐up. Advancements in liquid chromatography and mass spectrometry have accelerated and improved drug discovery and development. Identification and quantitation of drugs and metabolites have gained importance because of their relevance to clinical research. In the present review, we present a bird's eye view of qualitative and quantitative analysis of drugs and their metabolites. Various technologies available to characterize and quantitate metabolites are analyzed. Characterization of metabolites of the sulfonyl urea drug glyburide and the kinetics of glyburide metabolism are discussed in detail. Copyright © 2014 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/bmc.3309 |
| format | article |
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Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for the routine analysis of drugs and metabolites in the drug discovery set‐up. Advancements in liquid chromatography and mass spectrometry have accelerated and improved drug discovery and development. Identification and quantitation of drugs and metabolites have gained importance because of their relevance to clinical research. In the present review, we present a bird's eye view of qualitative and quantitative analysis of drugs and their metabolites. Various technologies available to characterize and quantitate metabolites are analyzed. Characterization of metabolites of the sulfonyl urea drug glyburide and the kinetics of glyburide metabolism are discussed in detail. Copyright © 2014 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0269-3879</identifier><identifier>EISSN: 1099-0801</identifier><identifier>DOI: 10.1002/bmc.3309</identifier><identifier>PMID: 25175001</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Chromatography, Liquid - methods ; drug discovery ; Drug Discovery - methods ; liquid chromatography ; mass spectrometry ; Mass Spectrometry - methods ; metabolites ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - chemistry ; Pharmaceutical Preparations - metabolism ; technologies</subject><ispartof>Biomedical chromatography, 2014-11, Vol.28 (11), p.1547-1553</ispartof><rights>Copyright © 2014 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4299-1b269386560e4b1bd76ccd7b09413b52c293b96c6b167ad908e89ff6910c9c5a3</citedby><cites>FETCH-LOGICAL-c4299-1b269386560e4b1bd76ccd7b09413b52c293b96c6b167ad908e89ff6910c9c5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25175001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ravindran, Selvan</creatorcontrib><creatorcontrib>Jadhav, Amol</creatorcontrib><creatorcontrib>Surve, Prashant</creatorcontrib><creatorcontrib>Lonsane, Ganesh</creatorcontrib><creatorcontrib>Honrao, Pradnya</creatorcontrib><creatorcontrib>Nanda, Bidyut</creatorcontrib><title>Technologies and strategies to characterize and quantitate metabolites in drug discovery and development</title><title>Biomedical chromatography</title><addtitle>Biomed. Chromatogr</addtitle><description>ABSTRACT
Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for the routine analysis of drugs and metabolites in the drug discovery set‐up. Advancements in liquid chromatography and mass spectrometry have accelerated and improved drug discovery and development. Identification and quantitation of drugs and metabolites have gained importance because of their relevance to clinical research. In the present review, we present a bird's eye view of qualitative and quantitative analysis of drugs and their metabolites. Various technologies available to characterize and quantitate metabolites are analyzed. Characterization of metabolites of the sulfonyl urea drug glyburide and the kinetics of glyburide metabolism are discussed in detail. Copyright © 2014 John Wiley & Sons, Ltd.</description><subject>Chromatography, Liquid - methods</subject><subject>drug discovery</subject><subject>Drug Discovery - methods</subject><subject>liquid chromatography</subject><subject>mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>metabolites</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - metabolism</subject><subject>technologies</subject><issn>0269-3879</issn><issn>1099-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp10E1LAzEQBuAgiq1V8BfIHr2sTjbd7Oao9ROqglR6DEl22kb3oyapWn-9a1t78zQM8_AyvIQcUzijAMm5rswZYyB2SJeCEDHkQHdJFxIuYpZnokMOvH8FAMGTbJ90kpRmKQDtktkIzaxuymZq0UeqLiIfnAq4WkMTmZlyygR09htX5_eFqoMNLYkqDEo3pQ0ttXVUuMU0Kqw3zQe65QoX-IFlM6-wDodkb6JKj0eb2SMvN9ejwV08fLq9H1wMY9NP2s-pbn9mOU85YF9TXWTcmCLTIPqU6TQxiWBacMM15ZkqBOSYi8mECwpGmFSxHjld5xrXeO9wIufOVsotJQX5W5Zsy5K_ZbX0ZE3nC11hsYV_7bQgXoNPW-Ly3yB5-TDYBG689QG_tl65N8kzlqVy_Hgrx306en68e5ZX7Aenu4P-</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Ravindran, Selvan</creator><creator>Jadhav, Amol</creator><creator>Surve, Prashant</creator><creator>Lonsane, Ganesh</creator><creator>Honrao, Pradnya</creator><creator>Nanda, Bidyut</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201411</creationdate><title>Technologies and strategies to characterize and quantitate metabolites in drug discovery and development</title><author>Ravindran, Selvan ; Jadhav, Amol ; Surve, Prashant ; Lonsane, Ganesh ; Honrao, Pradnya ; Nanda, Bidyut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4299-1b269386560e4b1bd76ccd7b09413b52c293b96c6b167ad908e89ff6910c9c5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Chromatography, Liquid - methods</topic><topic>drug discovery</topic><topic>Drug Discovery - methods</topic><topic>liquid chromatography</topic><topic>mass spectrometry</topic><topic>Mass Spectrometry - methods</topic><topic>metabolites</topic><topic>Pharmaceutical Preparations - analysis</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical Preparations - metabolism</topic><topic>technologies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ravindran, Selvan</creatorcontrib><creatorcontrib>Jadhav, Amol</creatorcontrib><creatorcontrib>Surve, Prashant</creatorcontrib><creatorcontrib>Lonsane, Ganesh</creatorcontrib><creatorcontrib>Honrao, Pradnya</creatorcontrib><creatorcontrib>Nanda, Bidyut</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biomedical chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ravindran, Selvan</au><au>Jadhav, Amol</au><au>Surve, Prashant</au><au>Lonsane, Ganesh</au><au>Honrao, Pradnya</au><au>Nanda, Bidyut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Technologies and strategies to characterize and quantitate metabolites in drug discovery and development</atitle><jtitle>Biomedical chromatography</jtitle><addtitle>Biomed. Chromatogr</addtitle><date>2014-11</date><risdate>2014</risdate><volume>28</volume><issue>11</issue><spage>1547</spage><epage>1553</epage><pages>1547-1553</pages><issn>0269-3879</issn><eissn>1099-0801</eissn><abstract>ABSTRACT
Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for the routine analysis of drugs and metabolites in the drug discovery set‐up. Advancements in liquid chromatography and mass spectrometry have accelerated and improved drug discovery and development. Identification and quantitation of drugs and metabolites have gained importance because of their relevance to clinical research. In the present review, we present a bird's eye view of qualitative and quantitative analysis of drugs and their metabolites. Various technologies available to characterize and quantitate metabolites are analyzed. Characterization of metabolites of the sulfonyl urea drug glyburide and the kinetics of glyburide metabolism are discussed in detail. Copyright © 2014 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25175001</pmid><doi>10.1002/bmc.3309</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-3879 |
| ispartof | Biomedical chromatography, 2014-11, Vol.28 (11), p.1547-1553 |
| issn | 0269-3879 1099-0801 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_bmc_3309 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Chromatography, Liquid - methods drug discovery Drug Discovery - methods liquid chromatography mass spectrometry Mass Spectrometry - methods metabolites Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism technologies |
| title | Technologies and strategies to characterize and quantitate metabolites in drug discovery and development |
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