Simultaneous detection of sulfoxaflor and its metabolites, X11719474 and X11721061, in lettuce using a modified QuEChERS extraction method and liquid chromatography–tandem mass spectrometry

• Published in: Biomedical chromatography 2017-06, Vol.31 (6), p.n/a
• Main Authors: Kim, Sung‐Woo, Rahman, Md. Musfiqur, Abd El‐Aty, A. M., Kabir, Md. Humayun, Na, Tae Woong, Choi, Jeong‐Heui, Shin, Ho‐Chul, Shim, Jae‐Han
• Format: Article
• Language: English
• Subjects: Chromatography, Liquid - methods; half‐life; Lactuca - chemistry; lettuce; Limit of Detection; liquid chromatography–tandem mass spectrometry; Pyridines - analysis; Pyridines - metabolism; QuEChERS; Reproducibility of Results; residues; Stereoisomerism; sulfoxaflor, metabolites; Sulfur Compounds - analysis; Sulfur Compounds - metabolism; Tandem Mass Spectrometry - methods
• ISSN: 0269-3879; 1099-0801
• DOI: 10.1002/bmc.3885

An analytical method has been developed to quantify the residual levels of sulfoxaflor and its metabolites (X11719474 and X11721061) in/on cultivated lettuce grown under greenhouse conditions. Samples were extracted and purified using a quick, easy, cheap, effective, rugged, and safe ‘QuEChERS’ method (original version) following systematic method optimization and were analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Good linearity with coefficient of determination ≥0.9930 was obtained and the limits of detection (LOD) and quantification (LOQ) were in the ranges of 0.003–0.006 and 0.01–0.02 mg/kg, respectively. The recovery rates of both the parent compound and its metabolites (fortified at 10 and 50× the LOQ) estimated from six replicates ranged between 81.9 and 115.5% with a relative standard deviation