Pharmacokinetic and metabolic profiling studies of osmundacetone in rats by UPLC–MS/MS and UPLC–QE–Orbitrap–HRMS

Osmundacetone is a potential medicinal substance existing in ferns and has excellent antioxidant effects. This research aims to obtain the pharmacokinetic data for and metabolite products of osmundacetone. An UPLC–MS/MS quantitative method was established for the measurement of osmundacetonein in ra...

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Bibliographic Details
Published in:Biomedical chromatography 2022-01, Vol.36 (1), p.e5251-n/a
Main Authors: Wu, Hao, Cao, Yijia, Wang, Jiaqi, Liu, Runhua, Sun, Yu, Zhang, Chenning, Sun, Yikun
Format: Article
Language:English
Subjects:
Animals
Chromatography, High Pressure Liquid - methods
Ketones - blood
Ketones - chemistry
Ketones - pharmacokinetics
Limit of Detection
Linear Models
Male
metabolism
osmundacetone
pharmacokinetics
Rats
Rats, Wistar
Reproducibility of Results
Tandem Mass Spectrometry - methods
UPLC–MS/MS
UPLC–QE–Orbitrap–HRMS
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Summary:Osmundacetone is a potential medicinal substance existing in ferns and has excellent antioxidant effects. This research aims to obtain the pharmacokinetic data for and metabolite products of osmundacetone. An UPLC–MS/MS quantitative method was established for the measurement of osmundacetonein in rat plasma over a linear range of 6.72–860.00 ng/ml. The signal to noise ratio of the lower limit of quantification was 60:1, the precision was
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.5251