Cancer Chemopreventive Activity of Serratane-Type Triterpenoids from Picea jezoensis

To search for cancer chemopreventive agents from natural sources, 13α,14α‐epoxy‐21α‐methoxyserratan‐3‐one, 21α‐methoxyserrat‐13‐en‐3‐one, and 21α‐hydroxy‐3β‐methoxyserrat‐14‐en‐30‐al isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis (Pinaceae) were investigated for i...

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Bibliographic Details
Published in:Chemistry & biodiversity 2004-06, Vol.1 (6), p.878-885
Main Authors: Tanaka, Reiko, Minami, Toshifumi, Ishikawa, Yohei, Tokuda, Harukuni, Matsunaga, Shunyo
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Animals
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cell Line, Tumor
Drug Screening Assays, Antitumor
Female
Mice
Mice, Inbred ICR
Picea
Triterpenes - chemistry
Triterpenes - isolation & purification
Triterpenes - pharmacology
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Summary:To search for cancer chemopreventive agents from natural sources, 13α,14α‐epoxy‐21α‐methoxyserratan‐3‐one, 21α‐methoxyserrat‐13‐en‐3‐one, and 21α‐hydroxy‐3β‐methoxyserrat‐14‐en‐30‐al isolated from the cuticle of Picea jezoensis (Sieb. et Zucc.) Carr. var. jezoensis (Pinaceae) were investigated for inhibitory effects in a two‐stage mouse skin carcinogenesis test on mouse skin with 7,12‐dimethylbenz[a]anthracene (DMBA) as initiator and 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) as promoter. 21α‐hydroxy‐3β‐methoxyserrat‐14‐en‐30‐al and 13α,14α‐epoxy‐21α‐methoxyserratan‐3‐one were found to exhibit strong antitumor‐promoting activities in the in vivo carcinogenesis test.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.200490070