Front Cover: Design, Synthesis, and Antitumor Activities of Isomers of Artemisinin Dimer Derivatives (Chem. Biodiversity 7/2023)

Front Cover. Artemisinin is extracted from Artemisia annua L. Its derivative, dihydroartemisinin (DHA), is divided into α and β configuration based on the orientation of hydroxy groups on the 10th carbon. Starting from DHA as the raw material, modifications of the C‐10 position were made, and artemi...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-07, Vol.20 (7), p.n/a
Main Authors: Yue, Lingyun, Pan, Yanna, Wang, Jiaoying, Yue, Lin, Luo, Yuxuan, Lv, Fang, Lv, Jiagang, Chen, Jianping, Zhao, Qingjie, Lin, Haixia
Format: Article
Language:English
Subjects:
antitumor activity
artemisinin dimer derivatives
chirality
configuration
dihydroartemisinin
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Summary:Front Cover. Artemisinin is extracted from Artemisia annua L. Its derivative, dihydroartemisinin (DHA), is divided into α and β configuration based on the orientation of hydroxy groups on the 10th carbon. Starting from DHA as the raw material, modifications of the C‐10 position were made, and artemisinin dimer derivatives with varying chiral structures were synthesized by linking different motifs. The study of structure–activity relationship showed that the β,β and α,β configurations were more effective in inhibiting tumor growth compared to the α,α configuration as presented by Lingyun Yue et al. in their research article at 10.1002/cbdv.202300615.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300976