Pregnane C 21 -Steroids with Anti-Inflammatory Activity from the Roots of Cynanchum bungei

Five pregnane C -steroids, including three 5,6-epoxy steroids (1-3) and two 8,14-seco-steroids (4 and 5), were isolated from the acid hydrolysate of Cynanchum bungei roots. Cynbungenins L-O (1-4) are previously undescribed compounds. Compound 3 with a 5α,6α-epoxy group represents the first example f...

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Published in:Chemistry & biodiversity 2025-01, p.e202403412
Main Authors: Li, Xiao-San, Zhang, Ai-Ling, Yuan, Wei-Bin, Feng, Wan-Bi, Zheng, Tong-Xin, Cai, Hai-Tao, Lin, Zi-Xin, Zhang, Yu-Bo, Lan, Cai-Yun, Yan, Chong
Format: Article
Language:English
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Summary:Five pregnane C -steroids, including three 5,6-epoxy steroids (1-3) and two 8,14-seco-steroids (4 and 5), were isolated from the acid hydrolysate of Cynanchum bungei roots. Cynbungenins L-O (1-4) are previously undescribed compounds. Compound 3 with a 5α,6α-epoxy group represents the first example found in the Cynanchum plants. Their structures and absolute configurations were elucidated by a variety of spectroscopic analysis and theoretical ECD calculations. All compounds (1-5) were evaluated for their anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) released in RAW264.7 cells. The results showed that they all possessed NO inhibitory activity at 50 µM, and compounds 3 and 4 exhibited stronger NO inhibitory activity than indomethacin.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202403412