Evidence for the Combined Participation of a C 10 and a C 15 Precursor in the Biosynthesis of Moenocinol, the Lipid Part of the Moenomycin Antibiotics

Upon feeding of [2‐ 13 C,4‐ 2 H]‐1‐deoxy‐ D ‐xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C 25 structure of moenocinol is assembled from...

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Published in:Chembiochem : a European journal of chemical biology 2003-11, Vol.4 (11), p.1201-1205
Main Authors: Neundorf, Ines, Köhler, Christian, Hennig, Lothar, Findeisen, Matthias, Arigoni, Duilio, Welzel, Peter
Format: Article
Language:English
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Summary:Upon feeding of [2‐ 13 C,4‐ 2 H]‐1‐deoxy‐ D ‐xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C‐7 and C‐17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C 25 structure of moenocinol is assembled from a C 10 and a C 15 precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200300622