Versatile Gold Surface Approach for Fabrication and Interrogation of Glycoarrays

Glycoarrays on gold: A designer gold surface incorporating a self‐assembled monolayer with weak protein absorption properties has been optimised for rapid display and interrogation of both native and derivatised glycans in array formats. This rapid, facile approach has diverse applications in glycom...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2008-07, Vol.9 (10), p.1568-1575
Main Authors: Zhi, Zheng-Liang, Laurent, Nicolas, Powell, Andrew K, Karamanska, Rositsa, Fais, Margherita, Voglmeir, Josef, Wright, Adam, Blackburn, Jonathan M, Crocker, Paul R, Russell, David A, Flitsch, Sabine, Field, Rob A, Turnbull, Jeremy E
Format: Article
Language:English
Subjects:
arrays
Carbohydrate Conformation
carbohydrates
fluorescence
Glycolipids - chemistry
Glycoproteins - chemistry
Glycosides - chemistry
Gold
MALDI-MS
Metal Nanoparticles - chemistry
Polysaccharides - chemistry
Protein Binding
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
surface plasmon resonance
Surface Properties
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Summary:Glycoarrays on gold: A designer gold surface incorporating a self‐assembled monolayer with weak protein absorption properties has been optimised for rapid display and interrogation of both native and derivatised glycans in array formats. This rapid, facile approach has diverse applications in glycomics, through exploitation of fluorescence, SPR and MALDI‐ToF MS detection methods.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200700788