Cover Feature: Effect of UV Radiation on Fluorescent RNA Aptamers’ Functional and Templating Ability (ChemBioChem 20/2019)

On the prebiotic earth, the earliest replicating molecules were likely made of RNA. Several lines of evidence suggest that life emerged on the surface exposed to substantial UV radiation from the young sun. In this study, UV damage decreased the activity and folding of functional RNA, but the rate a...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2019-10, Vol.20 (20), p.2530-2530
Main Authors: Saha, Ranajay, Chen, Irene A.
Format: Article
Language:English
Subjects:
biological chemistry
chemical biology
functional RNA aptamers
prebiotic evolution
UV damage
Online Access:Get full text
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Summary:On the prebiotic earth, the earliest replicating molecules were likely made of RNA. Several lines of evidence suggest that life emerged on the surface exposed to substantial UV radiation from the young sun. In this study, UV damage decreased the activity and folding of functional RNA, but the rate and extent of damage were highly variable, depending on both sequence and structure. Exposure to UV radiation would have represented an important selective pressure within the emerging RNA world. More information can be found in the full paper by I. A. Chen and R. Saha on page 2609 in Issue 20, 2019 (DOI: 10.1002/cbic.201900261).
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201900539